a tool for identifying drug-targetable redox-active disulphides

Minor allergen Can f 2

Intramolecular

Cysteine 82 and cysteine 175

A redox-regulated disulphide may form within Minor allergen Can f 2 between cysteines 82 and 175 (64 and 157 respectively in this structure).

Details

Redox score ?

92

PDB code

Structure name

crystal structure of the dog lipocalin allergen can f 2 and implications for cross-reactivity to the cat allergen fel d 4

Structure deposition date

2009-12-21

Thiol separation (Å)

2

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

82

Residue number B

175

Peptide name

Minor allergen Can f 2

Ligandability

Cysteine 82 of Minor allergen Can f 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of Minor allergen Can f 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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